Journal: Nature Communications

Article Title: Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models

doi: 10.1038/s41467-025-65936-0

Figure Lengend Snippet: a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface electrocardiograms recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.

Article Snippet: After obtaining stable ECG signals from the rats, adenosine (1 mg/kg, HY-B0228, MCE) was rapidly injected via the tail vein.

Techniques: Comparison, Two Tailed Test

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Schematic of a typical mouse electrocardiogram (ECG) showing the various parameters measured in this study. Signals through atria are shown in fuchsia and ventricular signals are in black and blue.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques:

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Representative ECG at 12 weeks from male uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC (blue). Similar changes were observed in female mice. Black arrow shows a prolonged T wave. Black dots represent baseline.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Infection

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Changes in atrial electrical activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panels ( A , B ) show P wave amplitude and duration. Panel ( C ) shows corrected PRc interval and Panel ( D ) shows PR segment. Data shown are mean ± SEM, with n = 8 mice per group (four males and four females). The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. Black arrows indicate the start of DTG/TDF/FTC treatment. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Activity Assay, Infection, Software, Control

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Changes in ventricular depolarization/repolarization activity of the ECG in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC. Panel ( A ) shows QRS complex, Panel ( B ) shows the S wave amplitude, Panel ( C ) shows J wave amplitude and Panel ( D ) shows QTc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Activity Assay, Infection, Software, Control

Journal: International Journal of Molecular Sciences

Article Title: Prolonged QT Interval in HIV-1 Infected Humanized Mice Treated Chronically with Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine †

doi: 10.3390/ijms27010519

Figure Lengend Snippet: Changes in ventricular repolarization/electrical silent region of the ECG (latter) in hearts from uninfected controls (green), HIV-1-infected (red), and HIV-1-infected Hu-mice treated with DTG/TDF/FTC (blue). Panel ( A ) shows STc interval, Panel ( B ) shows the ST-Tc segment, Panel ( C ) shows TPc interval and Panel ( D ) shows TQc interval. Data shown are mean ± SEM, with n = 8 mice per group, four males, and four females. Black arrows indicate the start of DTG/TDF/FTC treatment. The FUJIFILM Visual Sonics offline software Vevo LAB 5.7.1 was used to obtain parameter values. * Denotes significantly different from uninfected (control), p < 0.05; # denotes significantly different from HIV-1-infected, p < 0.05.

Article Snippet: Lead II ECG signals were recorded using a Fujifilm Visual Sonics Vevo 3100 system and accompanying THM150 Physiology Monitoring System (Fujifilm Visual Sonics, Toronto, ON, Canada).

Techniques: Infection, Software, Control

Journal: Bioengineering

Article Title: Deep Learning-Based Fatigue Monitoring in Natural Environments: Multi-Level Fatigue State Classification

doi: 10.3390/bioengineering12121374

Figure Lengend Snippet: ECG signal before and after pre-processing.

Article Snippet: ECG signal acquisition is facilitated by the ultra-low power integrated analog front-end AFE4900 (Texas Instruments, Dallas, TX, USA) from TI.

Techniques:

Journal: Bioengineering

Article Title: Deep Learning-Based Fatigue Monitoring in Natural Environments: Multi-Level Fatigue State Classification

doi: 10.3390/bioengineering12121374

Figure Lengend Snippet: The ECG signal with R points marked.

Article Snippet: ECG signal acquisition is facilitated by the ultra-low power integrated analog front-end AFE4900 (Texas Instruments, Dallas, TX, USA) from TI.

Techniques:

Journal: Bioengineering

Article Title: Deep Learning-Based Fatigue Monitoring in Natural Environments: Multi-Level Fatigue State Classification

doi: 10.3390/bioengineering12121374

Figure Lengend Snippet: Ecg electrodes.

Article Snippet: ECG signal acquisition is facilitated by the ultra-low power integrated analog front-end AFE4900 (Texas Instruments, Dallas, TX, USA) from TI.

Techniques: